Name: Sim
Sex: Male
Nationality: Korean
Age: 56Y
Diagnosis: Parkinson Syndrome
Discharge Date: 2018/01/29

Before treatment:
The patient felt stiff and weak in his left leg, he walked slowly and it affected his daily life. He went to a local hospital and was diagnosed with Parkinson's disease. His condition improved after he took Madopa but overall his condition still got worse and his right leg became weak too. He went to some hospitals and did treatments but the treatment effect was not good enough. In the past two months he spoke slowly, walked in an unstable manner and felt weak in his legs.
His diet is irregular, his sleep is not good with him sleeping around 5 hours each night. He can’t control urination or defecation functions well and he feels upset sometimes.

Admission PE:
Bp: 142/86mmHg, Hr: 80/min, body temperature: 36.3 degrees. Breathing rate: 18/min. He displayed a mild humpbacked posture when he was standing. His walking gait was slightly clumsy with very poor arm swing movement, he could turn around or cross some barriers slowly. His nutrition status was fine, there is no broken or bleeding spots of his skin and mucosa, no lymph nodes swollen and no tonsil swelling. The respiratory sounds in both lungs were clear with no dry or moist rales. The heart beat is powerful with regular cardiac rhythm and no obvious murmur in the valves. The abdomen was flat and soft with no tenderness, rebound tenderness or masses. The liver and spleen were in the normal position by touch and there was no edema of the legs.

Nervous System Examination:
Patient was alert, had clear speech but sometimes he spoke slowly. His orientation, cognitive function and calculation abilities were normal. Both pupils were equal and round, diameter of 3.0 mm, react well to light, and eyeballs can move freely. There was no nystagmus. Bilateral forehead wrinkle and nasolabial fold are symmetrical, he could make his tongue extend out  but his tongue cannot move as well as normal. Bilateral soft palate could lift powerfully, the uvula was normal, he could turn his head and shrug as normal and there was no obvious body tremor. The  muscle power of the arms was 5 degrees, left leg muscle power was 4 degrees, right leg was 4+ degrees. It was difficult to move his left leg when he rolled over in bed, tried to get up from bed or walk but he did not need assistance. The 4 limbs muscle tone was normal, the bilateral biceps reflex, triceps reflex and radial periosteal reflex were normal. His patellar tendon reflex and Achilles tendon reflex were lower than normal, the bilateral Hoffmann signs were negative. The Rossilimo sign of both sides were negative and sucking reflex was negative. The bilateral palm-jaw reflex and Babinski sign were negative. His deep and superficial sensory and fine sensory were normal. The bilateral fast alternate movement and finger to nose test were flexible. The left hand finger opposite movement was flexible, right hand finger opposite movement was slow. The heel-knee-tibia test on both sides were less stable, the Romberg's sign was positive. He would easily fall down when pushed backward and he tended to lean to the right and backwards when he was walking. The standing test using just the left leg was difficult, he could not walk straight in a steady manner. The meningeal irritation sign was negative.

Treatment:
After the admission he received 3 nerve regeneration treatments (neural stem cells and mesenchymal stem cells) to repair his damaged nerves, replace dead nerves with new injected stem cells, nourish nerves, regulate his immune system and improve blood circulation. His treatment included rehabilitation training.     

Post-treatment:
After 12 days treatment the patient's condition was stable, his voice was louder and clearer, his arms were more flexible, his legs were less stiff. He moved faster, his balance and walking gait improved. He now slept 7-8 hours per night. Both his spirit and exercise tolerance were improved.