Sandra Lang-Parkinson's Disease-(America)

Author Zhangqi Views Posted at 2019/07/17

Name: Sandra Lang
Sex: Female
Nationality: American
Age: 75Y
Diagnosis: Parkinson's Disease
Discharge Date: 2019/06/09

Before treatment:
After a second knee replacement in 2016 the patient developed bilateral lower limb weakness, unstable balance, aggravated symptoms, progressive weakness and joint stiffness. She was diagnosed with Parkinson's disease in many hospitals and treated with levodopa / carbidopa 100/25mg three times a day. Her joint stiffness and motor retardation improved after treatment. Stem cell therapy was performed in California in October 2018 and there has been a slight improvement after the treatment. At present she has muscle stiffness, slow movement, slow walking, writing difficulties, unstable balance and other problems.
She has a regular diet, sleeps well and her urination and defecation functions are normal.

Admission PE:
Bp: 143/78mmHg, pulse rate: 60/min, breathing rate 19/min. Height 165cm, weight 94.5kg. The patient has good nutrition status, no ecchymosis or bleeding spots of the skin or mucosa, no congestion of the throat, no swelling of the tonsils, clear respiratory sounds of both lungs, and no dry or moist rales were heard. She has strong heart sounds with no murmur heard in the valves, a soft abdomen, no tenderness and masses, normal liver and spleen, negative shifting dullness and no edema of the legs.

Nervous System Examination:
The patient was alert, had clear speech with normal speed, normal articulation and normal memory, calculation and orientation ablities. Both pupils were round and equal in size, with a diameter of 3 mm, react sensitively to light, with free eyeball movement and no nystagmus. The forehead wrinkle and nasolabial fold were symmetrical. There was no muscle tremor in the tongue, flexible tongue muscle movement, no deviation when showing teeth and extending the tongue out, strong power to reach the cheeks with the tongue, normal soft palate-lifting and no deviation in uvula. She had strong neck-turning and a strong shrug. The 4 limbs’ display bradykinesia and rigidity with grade 5 muscle power. She is slow turning over, getting up, walking, body-turning and has a limping walking gait. There is normal muscle tone of both arms, high muscle tone of the legs, the abdominal reflex could not be induced, there was normal biceps reflex, triceps reflex, radioperiosteal reflex, knee tendon reflex and heel tendon reflex bilaterally. She has a positive Rossilomo sign and palm-jaw reflex bilaterally, negative Hoffmann sign and sucking reflex bilaterally and an enhanced positive Babinski sign bilaterally. There was normal deep, shallow and fine sensation bilaterally by gross examination with lightly clumsy fast alternate bilaterally. She has accurate and stable finger to finger and finger to nose tests bilaterally. Bilateral heel-knee-tibia test was done slowly. Negative Romberg's sign and meningeal irritation sign.

Treatment:
After the admission she received 3 nerve regeneration treatments (neural stem cells and mesenchymal stem cells) to repair her damaged brain nerves, replace dead nerves, nourish nerves (ganglioside, nerve growth factors and neurotrophic factors), improve body environment, regulate her immune system and improve blood circulation. This was combined with rehabilitation training.

Post-treatment:
After 14 days treatment the rigidity in the legs alleviated, there was more flexible limb movement, remarkable alleviation of bradykinesia, the walking gait was nearly normal and she had better balance. She initially needed 4-5 steps to do a turn but now she only needs 1 step and she can walk better.